The toll type 4 (TLR4) receiver, a key model recognition receiver, initiates the innate immune response and leads to chronic and acute inflammation. In recent decades, the accumulation of evidence involved an inflammatory intervention mediated by the TLR4 in the regulation of the hypertrophic renovation of myocardium, indicating that the regulation of the TLR4 signaling path can be an effective strategy for the management of the physiopathology of Cardiac hypertrophy. Given the meaning of TLR4, it is imperative to examine the molecular mechanisms and roles underlying TLR4 signaling in cardiac hypertrophy. We examine here exhaustively the current knowledge of the TLR4 inflammatory response and its interaction ligands and co-receptors, as well as the activation of various intracellular signals.
We also describe the associated roles in promoting the secretion of infiltration of immune cells and the secretion of inflammatory mediators, which ultimately cause cardiac hypertrophy. Finally, we provide examples of some of the most promising medicines and new technologies that could mitigate the TLR4-mediated inflammatory response and prevent or reversed the results of winding heart hypertrophy. Porphyromonas Gingivalais MFA1 Fimbriae are considered to be adhesion factors and direct destruction of periodontal tissues, but their immunomodulatory actions are poorly understood. Here we have studied the effect of the stimulation of the MFA1 on the immunodevalent and metabolic mechanisms of gingival fibroblasts of periodontal connective tissue.
We also determined the toll (TLR) 2 and TLR4 receptor role in the recognition of the MFA1. MFA1 increased the expression of the coding genes of the chemokine (CXCL) 1, CXCL3, intercellular adhesion molecule (ICAM) 1 and selectin endothelium (E) in gingival fibroblasts, but did not have a significant effect on Genes that govern metabolism.
The toll receiver 2 at the crossroads between cancer cells, the immune system and the microbiota
The toll receiver 2 (TLR2) expressed on mediocre myeloid cells the recognition of harmful molecules belonging to invasive pathogens or to accommodate damaged tissues, resulting in inflammation. For this ability to activate immune responses, TLR2 has been considered an anti-cancer immunity player. As a result, TLR2 agonists were used as adjuvants for anticancer immunotherapy. However, the TLR2 is also expressed on neoplastic cells of different malignant tumors and promotes their proliferation thanks to the activation of the primary reaction protein of myeloid differentiation 88 (myd88) / Nuclear factor Kappa-light-chain-chain-valorization from the channel B activate d (NF-κB). In addition, its activation on regulatory immune cells can contribute to the generation of an immunosuppressive microenvironment and the pre-metastatic niche, promoting the progression of cancer.
Thus, TLR2 represents a double-edge sword, whose role in cancer must be carefully understood for the configuration of effective therapies. In this review, we discuss diverging effects induced by the activation of TLR2 in different populations of immune cells, cancer cells and cancer stem cells. In addition, we analyze the stimuli that lead to its activation in tumor microenvironment, responding to the role of molecular patterns of danger, pathogen and microbiota and their modulation during cancer treatments. This information will contribute to the scientific debate on the use of TLR2 agonists or cancer treatment antagonists and pave the way for new therapeutic pathways.
Key Player in Cardiac Hypertrophy, Emphasizing the Role of Toll-Like Receptor 4
The type 7 receiver 7 is required for the development of self-immunization of lacrimal gland and type 1 diabetes in unplugged diabetic mice male
Sjögren Syndrome (SS) is an immunologically complex chronic autoimmune disease targeting lacrimal and salivary glands. Non obese diabetic mice spontaneously develop an inflammation of lacrimal and salivary glands with histopathological characteristics similar to SS in humans, including focal length infiltrates in the affected glands. Innés immune signals resulting in lymphocytic infiltration of these glands are not well defined. Here we evaluate the role of toll receptor (TLR) 7 in the development of SS-like manifestations in the nocturnal mice.
We have created a Knockout TLR7 hoche the deformation of the mouse and conducted histological and gene studies in order to characterize the effects of the TLR7 on the automatic self-immunity development. The TLR7 was necessary for a lacrymal gland inflammation specific to men but not for women’s salivary gland inflammation. In addition, TLR7 was required for the development of type 1 diabetes in male but non-female holed mice. The sequencing of the RNA has shown that the TLR7 was associated with an interferon response of type I (IFN) and a cell I cell response. IFN IFN in the lacrimal glands. Together, these studies identify a previously not appreciated pathogenic role for the TLR7 in lacrimal self-immunities and the development of the T1D in the manh mice Nok Simped to the growing set of evidence supporting sexual differences from self-immune disease mechanisms.
Interleukin 18 Receptor 1 (IL18R1) Antibody
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abx173115-100l
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abx210847-100l
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abx211998-100l
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abx213451-100g
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Interleukin 18 Receptor 1 (IL18R1) Antibody
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abx270098-1ml
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abx270098-200l
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Interleukin 18 Receptor 1 (IL18R1) Antibody
abx270182-1ml
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abx270182-200l
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Interleukin 18 Receptor 1 (IL18R1) Antibody
abx338848-100g
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abx338848-20g
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abx338848-50g
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abx323724-100g
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abx324052-100g
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abx270628-200l
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abx336171-100g
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abx336171-20g
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abx270396-200l
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abx270480-1ml
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abx270480-200l
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abx336172-100g
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abx336172-20g
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Interleukin 18 Receptor 1 (IL18R1) Antibody (Biotin)
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abx272170-200l
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abx272941-250mg
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abx272941-50mg
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abx336173-100g
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abx336173-20g
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abx336173-50g
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Interleukin 18 Receptor 1 (IL18R1) Monoclonal Antibody
CAU30738-100ul
Biomatik Corporation
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CAU30738-200ul
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Interleukin 18 Receptor 1 (IL18R1) Polyclonal Antibody
CAU25557-100ul
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CAU25557-200ul
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CAU25558-100ul
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CAU25558-200ul
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CAU25559-100ul
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CAU25559-200ul
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200ul
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CAU25560-100ul
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CAU25560-200ul
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200ul
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Polyclonal Antibody to Interleukin 18 Receptor 1 (IL18R1)
PAB652Hu01
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PAB652Hu02
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Monoclonal Antibody to Interleukin 18 Receptor 1 (IL18R1)
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4-PAB652Hu01-Cy3
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4-PAB652Hu01-HRP
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4-PAB652Hu02-APC
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Description: A Rabbit polyclonal antibody against Human Interleukin 18 Receptor 1 (IL18R1). This antibody is labeled with APC.
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4-PAB652Hu02-Cy3
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4-PAB652Hu02-HRP
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Description: A Rabbit polyclonal antibody against Human Interleukin 18 Receptor 1 (IL18R1). This antibody is labeled with HRP.
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4-PAB652Mu01-APC
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Description: A Rabbit polyclonal antibody against Mouse Interleukin 18 Receptor 1 (IL18R1). This antibody is labeled with APC.
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4-PAB652Mu01-Cy3
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Description: A Rabbit polyclonal antibody against Mouse Interleukin 18 Receptor 1 (IL18R1). This antibody is labeled with Cy3.
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4-PAB652Mu01-HRP
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100ul
10ml
1ml
200ul
20ul
Description: A Rabbit polyclonal antibody against Mouse Interleukin 18 Receptor 1 (IL18R1). This antibody is labeled with HRP.
Interleukin 18 Receptor 1 (IL18R1) Polyclonal Antibody (Mouse), APC
4-PAB652Mu02-APC
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100ul
10ml
1ml
200ul
20ul
Description: A Rabbit polyclonal antibody against Mouse Interleukin 18 Receptor 1 (IL18R1). This antibody is labeled with APC.
Interleukin 18 Receptor 1 (IL18R1) Polyclonal Antibody (Mouse), Cy3
4-PAB652Mu02-Cy3
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100ul
10ml
1ml
200ul
20ul
Description: A Rabbit polyclonal antibody against Mouse Interleukin 18 Receptor 1 (IL18R1). This antibody is labeled with Cy3.
Interleukin 18 Receptor 1 (IL18R1) Polyclonal Antibody (Mouse), HRP
4-PAB652Mu02-HRP
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100ul
10ml
1ml
200ul
20ul
Description: A Rabbit polyclonal antibody against Mouse Interleukin 18 Receptor 1 (IL18R1). This antibody is labeled with HRP.
Interleukin 18 Receptor 1 (IL18R1) Polyclonal Antibody (Human), FITC
4-PAB652Hu01-FITC
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100ul
10ml
1ml
200ul
20ul
Description: A Rabbit polyclonal antibody against Human Interleukin 18 Receptor 1 (IL18R1). This antibody is labeled with FITC.
Interleukin 18 Receptor 1 (IL18R1) Polyclonal Antibody (Human), FITC
4-PAB652Hu02-FITC
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100ul
10ml
1ml
200ul
20ul
Description: A Rabbit polyclonal antibody against Human Interleukin 18 Receptor 1 (IL18R1). This antibody is labeled with FITC.
Interleukin 18 Receptor 1 (IL18R1) Polyclonal Antibody (Mouse), FITC
4-PAB652Mu01-FITC
Cloud-Clone
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100ul
10ml
1ml
200ul
20ul
Description: A Rabbit polyclonal antibody against Mouse Interleukin 18 Receptor 1 (IL18R1). This antibody is labeled with FITC.
Interleukin 18 Receptor 1 (IL18R1) Polyclonal Antibody (Mouse), FITC
4-PAB652Mu02-FITC
Cloud-Clone
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100ul
10ml
1ml
200ul
20ul
Description: A Rabbit polyclonal antibody against Mouse Interleukin 18 Receptor 1 (IL18R1). This antibody is labeled with FITC.
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
20-abx104337
Abbexa
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100 ug
10 ug
1 mg
200 ug
50 ug
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
20-abx104338
Abbexa
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100 ug
10 ug
1 mg
200 ug
50 ug
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
20-abx128803
Abbexa
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100 ug
10 ug
1 mg
200 ug
50 ug
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx037127-100ug
Abbexa
100 ug
EUR 469.2
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx034109-400ul
Abbexa
400 ul
EUR 627.6
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx034109-80l
Abbexa
80 µl
EUR 343.2
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
20-abx213452
Abbexa
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Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
20-abx213453
Abbexa
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Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
20-abx173116
Abbexa
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Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
20-abx320230
Abbexa
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Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx104337-100g
Abbexa
100 µg
EUR 725
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx104337-20g
Abbexa
20 µg
EUR 262.5
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx104337-50g
Abbexa
50 µg
EUR 337.5
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx104338-100g
Abbexa
100 µg
EUR 725
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx104338-20g
Abbexa
20 µg
EUR 262.5
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx104338-50g
Abbexa
50 µg
EUR 337.5
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx173116-100l
Abbexa
100 µl
EUR 750
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx173116-1ml
Abbexa
1 ml
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Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx173116-200l
Abbexa
200 µl
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Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx213452-100g
Abbexa
100 µg
EUR 250
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx213453-100g
Abbexa
100 µg
EUR 250
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx128803-100l
Abbexa
100 µl
EUR 262.5
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx128803-1ml
Abbexa
1 ml
EUR 712.5
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx128803-200l
Abbexa
200 µl
EUR 325
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx037127-1096tests
Abbexa
10 × 96 tests
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Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx037127-596tests
Abbexa
5 × 96 tests
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Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx037127-96tests
Abbexa
96 tests
EUR 337.5
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx034109-100g
Abbexa
100 µg
EUR 281.25
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx320230-100l
Abbexa
100 µl
EUR 350
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
abx320230-50l
Abbexa
50 µl
EUR 237.5
Interleukin-18 Receptor Accessory Protein (CD218b) Antibody
20-abx121573
Abbexa
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Interleukin 18 Receptor 1 (IL18R1) Polyclonal Antibody (Human), APC-Cy7
4-PAB652Hu01-APC-Cy7
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100ul
10ml
1ml
200ul
20ul
Description: A Rabbit polyclonal antibody against Human Interleukin 18 Receptor 1 (IL18R1). This antibody is labeled with APC-Cy7.
Interleukin 18 Receptor 1 (IL18R1) Polyclonal Antibody (Human), APC-Cy7
4-PAB652Hu02-APC-Cy7
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100ul
10ml
1ml
200ul
20ul
Description: A Rabbit polyclonal antibody against Human Interleukin 18 Receptor 1 (IL18R1). This antibody is labeled with APC-Cy7.
Interleukin 18 Receptor 1 (IL18R1) Polyclonal Antibody (Mouse), APC-Cy7
4-PAB652Mu01-APC-Cy7
Cloud-Clone
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100ul
10ml
1ml
200ul
20ul
Description: A Rabbit polyclonal antibody against Mouse Interleukin 18 Receptor 1 (IL18R1). This antibody is labeled with APC-Cy7.
Interleukin 18 Receptor 1 (IL18R1) Polyclonal Antibody (Mouse), APC-Cy7
4-PAB652Mu02-APC-Cy7
Cloud-Clone
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100ul
10ml
1ml
200ul
20ul
Description: A Rabbit polyclonal antibody against Mouse Interleukin 18 Receptor 1 (IL18R1). This antibody is labeled with APC-Cy7.
After a nervous injury, a distal disintegrated axonal mitochondria on the injury site release the peptides and mitochondrial formylated DNAs that may induce activation and inflammatory Schwann cell profiling via the formyl peptide receptor 2 (FPR2) and the receiver 9 (TLR9), respectively. We studied RT4 Schwannoma cells to investigate the regulation of FPR2 and TLR9 after stimulation with FMLF as prototyped peptide.
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